寻找癌症的指纹
How comprehensive genomic profiling – through tissue and liquid-based approaches – is driving truly personalised cancer care.
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对于癌症患者，个性化护bob投注平台理比以往任何时候都更重要
有人说Covid-19是一个平等的机会疾病，带来了全球各个角落的痛苦。但病毒并不扮演公平 - 它不成比例地在脆弱的攻击中，包括癌症。液体活组织检查甚至有助于赔率。
Time can be a matter of life and death for cancer patients. Early detection and treatment are essential to improve outcomes, and consistent care is crucial. But the pandemic puts cancer patients at increased risk in three ways:
- 即使在正常时期，最近医院的旅行可能超过农村地区患者艰苦旅行的一天。bob投注平台在大流行的初期，几乎所有人和基础设施都会进入医疗保健 - 从过境到医疗保健 - 崩溃了。
- 锁定和负担过剩的医院防止患者寻求测试或治疗。bob投注平台有些人太害怕去，即使他们可以。
- 对于癌症患者 - 患者bob投注平台 - 患者是免疫抑制作用 - Covid-19和其他疾病感染的风险特别高，特别是在过度拥挤的空间中。
Since the pandemic, government and academic institutions report massive declines in cancer care globally. One学习表明，在18个国家的近61％的肿瘤学中心报告了在大流行的第一次峰值期间减少了临床活动，并且近三分之二被引用后治疗成为主要问题。
在ESMO虚拟大会2020中提出的数据，在同一研究中，表明，在癌症中心最有可能被取消或延迟的治疗在44％，化疗近26％和放疗近14％。姑息（生活质量）护理早些时候以32％的中心结束。
常规筛查也暴跌，降低了早期检测的几率，这转化为在稍后阶段诊断的人的生存赔率降低。
Other学习建议在3月和4月20日在美国的常规筛查预约中举行大约80％，可以捕获新的癌症。其他纸estimated that screening for breast, colon and cervical cancer in the U.S. dropped by about 60% from mid-March to mid-June 2020.
“对于患者bob投注平台来说，它全部关于癌症的时间......在他们疾病之旅的这一阶段，时间比任何事情更重要。”
寻找有需要的人的解决方案
世界各地的Roche附属公司早期认识到癌症患者在落后于竞争中留下的那些，以打击大流行。bob投注平台他们决心找到新的和创新的帮助。
“意大利的情况很困难;它是最艰难的国家之一，“罗氏精密医学品牌经理Luca Lattanzi说。
In some ways, it was the perfect storm for the pandemic: The risk of cancer increases with age, and almost a quarter (23.1%) of Italy’s population is estimated to be 65 years and older – the largest percentage of elderly in Europe in 2019. Research shows that coronavirus is more of a threat to older people, who, if they get the disease, are more likely to have a severe case.
“我们从我们自己的场力和医生s that cancer patients in Italy were not always able to go to hospitals to undergo testing or treatments,” Luca says. “The first lockdown was the spark that pushed us to think outside the box and come up with a way to help.”
其中一个解决方案？一种简单的血迹形式的液体活组织检查，通过旅行护士直接在患者的家中进行。护士到达指定的时间，绘制两节血液，并在四小时内为快递拾取包装。小瓶被送到一个特殊的实验室，该实验室可以测试肿瘤以进行基因组改变，让医生和患者更加了解目标治疗方案。
移动血液抽取如何工作
- Healthcare provider orders the liquid biopsy test; sends privacy consent forms to patient
- 患者通过电子邮件或视频/音频录制表格表格
- 患者信息将上传到安全系统
- 护士到达患者家庭套件和预先印刷的患者形式
- Nurse performs blood draw, fills the box and seals it, and leaves with any biowaste
- The blood sample is refrigerated by the patient and collected by courier within 4 hours.
每个癌症，像每个人一样，是独一无二的
Every person has a unique set of genetic instructions, called a genome. Cancer is a disease of the genome, caused by genomic alterations that make a tumour grow. Comprehensive genomic profiling, or CGP, is a powerful tool for proper diagnosis and treatment planning. It tests a tumour’s DNA for more than 300 genomic alterations, and offers a summary of treatment options based on the alterations identified. This gives the doctor and patient options for care that are tailored to the individual causes of the disease.
可以通过组织活组织检查进行综合基因组分析，其中组织样品取自侵入性，并且必须在医院或诊所进行。液体活组织检查（血液绘制）给予癌症的人是一种微创方式来鉴定靶向癌症治疗。例如，疾病已经进展的肺癌患者可能具有较少可用于活组bob投注平台织检查的组织，或者肿瘤可能在难以达到的位置。
“也有它的精神方面，”Paulo Neto，客户体验领先的个性化医疗保健和基础医学，罗氏集团的一部分。“人们对他们的家更舒适和自信。所以血液绘制在自己的空间，他们的庇护所。情绪部分非常重要;我们正在向他们提供他们的条款。我们正在谈论癌症患者，其中许多人在其条件下已经脆弱了。“bob投注平台
什么是液体活组织检查？
Comprehensive genomic profiling with liquid biopsies involves drawing only two vials of blood, and eliminates or minimises time spent in hospitals or clinics. For those who are already weak, it also removes the need to travel long distances for testing. The solution ensures privacy, gives patients safe, timely access to essential diagnostics, and provides invaluable insight to patients and their doctors to help personalise treatment.
How liquid biopsy works
液体活组织检查测试实体瘤;它检测患者血液中肿瘤脱落的循环肿瘤DNA。这使得综合基因组分布的选择，无论它们所在的位置还是大流行的情况如何。bob投注平台每个癌症都是独一无二的，这一创新使得真正个性化的癌症关心全球更多患者的现实。bob投注平台
In just two months, under lockdown conditions and in the midst of pandemic mayhem, the Roche Italy team launched a safe, secure and patient-focused mobile blood draw program that brought liquid biopsy testing to cancer patients in need.
“参与该项目的每个人都知道这个项目的价值和为我们患者提供解决方案的紧迫性，”卢卡说。bob投注平台“社会中的一些最脆弱的人有需要，速度至关重要。但患者隐私和安全性同样重要;这项项目绝对关键。我们很幸运，因为我们依赖于一家专门护士的国家网络，这已经在意大利与我们合作。
Timing is everything
在全球Roche附属公司发起的类似计划。在加拿大和西班牙，医院用Covid-19患者负担过重，患者的访问仅限于立即迫切需要。bob投注平台附属公司与局部输液诊所合作，确保患者可以在全国范围内的网络网络中预约，并在安全，方便的环境中接受液体活组织检查。bob投注平台
bob投注平台患者在线预订测试，并获得快乐的安心，知道快速，微创的测试将最大限度地减少他们感染的风险，并给予他们，以及他们的肿瘤科医生，了解基于疾病进展的个性化治疗决策的见解。
“For patients, it's all about time with cancer,” Paulo says. “Time is really critical for them. And many patients who undergo genomic testing, unfortunately, are in the late stages of disease. So they are looking at this test with the hope that it might open different possibilities. In this phase of their disease journey, time matters more than anything.”
大流行后
液体活检计划已经在某些国家已经存在了几年，服务于不容易到达医院或诊所的患者。bob投注平台该解决方案现已在大流行的压力下进行测试，将使患者更好地在未来的选择 - 以及他们的术语，莫罗布洛维利，精密医学客户服务团队协调员。bob投注平台
“I am absolutely convinced this solution can be just as practical in the following years, beyond the pandemic,” Mauro says. “The model in Italy works well; it works well in other places, and we will continue moving it forward. This helps our patients to be safe and to find answers more quickly. It gives us new ways to serve them, and puts the focus on the patient. In the end, that’s our focus, too.
Taking testing to those in need
在印度，大多数人口远离主要医院;大多数在外围地区的高等教育中心寻求治疗。Roche于2017年推出了一项移动血液抽奖计划，以更好地为人口服务。
但Covid-19带来了新的挑战，让程序跑步为患者服务。bob投注平台在锁定的早期，关于Covid-19存在很多不确定性;在国外送出的遗传物质的测试被政府视为“非必要”，同时只允许发货的“必要”项目。测试套件 - 其中包含在实验室的基因组测试的血液的血液 - 没有清楚的习俗，而是闲置。
“它是一个震惊;整个程序来到了一个停滞状态，“孟买治疗区域医疗专家-PHC说，Nippun Sandhir说。“但随时干预，该团队能够获得必要的文件，以便在15至20天内允许在印度的测试套件和在实验室的路上。对于我们来说，那些是极端不确定性的日子，我们知道没有选择，而是找一个解决方案。bob投注平台患者依赖它。“
在巴西，在多年前推出的移动血液抽取计划存在巨大差异。该国约有80％的液体活检测试通过移动血液抽取计划进行。
“For some years now, we have the possibility to have home care assistance collect the liquid biopsy,” says Viviane Pinto, Customer Services and Operations Coordinator for Foundation Medicine in São Paulo. “It is an alternative we offer to our patients, and they have the right to choose to either go to a laboratory facility or have a home care nurse complete the procedure. It is a service offered without any additional cost, and even though it is already available for some time, it was specially used during the pandemic in 2020.”
