Lung cancer patient standing outside

Finding cancer`s fingerprint

“我每天都想着它,但你试图把它放在一边,只需过你可以的最好的生活,”詹妮弗说,他的医生使用基因组测试来寻找癌症的目标治疗

Published 30 October 2020

几乎每个人都被癌症触及,无论是因为朋友或家人都被诊断出来,还是亲自与疾病一起生活。但是,虽然这种疾病在某种程度上普遍看来,但癌症本身就像指纹 - 作为被诊断患者的个体是独一无二的。癌症是基因组的疾病,由遗传突变驱动。这就是为什么基因组测试至关重要,以帮助理解癌症的潜在生物学,以便针对他们的治疗并提供个性化护理。

什么是癌症基因组测试?

一种cancer genomic test习惯了识别DNA突变在癌细胞内确定肿瘤如何表现和生长。这些见解可以增加可能性of optimising and individualising an informed patient care plan forindividuals with cancerbased on the specific mutations identified.

癌症 - 基因组 - 测试-740

综合基因组分析(CGP)是一种寻找癌症肿瘤独特的“指纹”的一种方式。使用肿瘤的活组织检查 - 用组织样品或血液检测 - CGP在大量癌症相关基因上搜索遗传突变,鉴定已知涉及致癌过程的那些,影响如何肿瘤的行为和生长。CGP的见解帮助医生细化他们的诊断,并提供预后信息以及对每个人的预测洞察力。这反过来允许医生与现有的有针对性疗法相匹配癌症突变,并排除不必要的疗法。通过CGP,治疗可以个性化以每个个人肿瘤的独特形式 - 匹配癌症的独特的“指纹”。了解更多here

癌症基因组测试可以帮助医生和患者:bob投注平台

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减少不确定性治疗方案,reby helping patients potentially avoid unnecessary or non-beneficial treatment.

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允许医生对个人独特的肿瘤特异的治疗,这可能导致改善的结果和生活质量。

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Providing confidence in the treatment journey for people living with cancer and their doctors.

詹妮弗与cgp的旅程

2016年,当詹妮弗在佛罗里达州前往孙子孙女时,她开发了一个咳嗽。在她回到加拿大的回家后,她拜访了她的医生,他告诉她如果咳嗽在三周内没有消失。咳嗽持续存在,她的医生向肿瘤科医生提到了她。虽然Jennifer从未吸烟过,但事实证明她有晚期肺癌(第四阶段)。

“It was one of those situations, as a never-smoker, where it’s a complete shock,” said her physician, Dr. Jeffrey Rothenstein, Medical Oncologist at the Durham Regional Cancer Centre, Oshawa, Canada. Both Jennifer and he had the question that nearly every cancer patient asks: “How can this be happening and why did this happen?” Rothenstein did some initial testing, including testing for single cancer-causing genes, and Jennifer was negative. No answers.

一种t that point, Dr. Rothenstein brought up the option of genomic testing. He explained to Jennifer that CGP would be able to identify the specific, unique DNA mutation profile within her cancer cells, which would help him guide decisions in a treatment plan. Dr. Rothenstein had started Jennifer on chemotherapy, and she’d responded to the treatment, but both wanted to be sure they had left no stone unturned in fighting the disease. Jennifer felt relieved to have another option.

当我与患者交谈时,当我与Jenbob投注平台nifer交谈时,我们谈到了我们对拥有工具箱的这个想法的基因组分析,并希望在治疗疾病的疗程中使用正确的治疗方法,“詹妮弗的医生说
Dr Jeffrey RothensteinMedical Oncologist at the Durham Regional Cancer Centre, Oshawa, Canada

“我是一个控制怪胎,”詹妮弗说:“我无法控制我的身体做得更多的事情。”她同意测试。“我需要有一个计划,”她告诉罗滕斯坦博士。

The CGP testing came back and revealed that Jennifer did have a specific mutation in her cancer that would respond to a targeted therapy. Targeted therapies treat cancer, interfering with the ability of cancer cells to grow and multiply, leading to the death of the cancer cells. While chemotherapy usually affects normal cells along with the cancer cells, targeted therapies impact only the cancer pathway that is driven by the specific genetic mutation. They are also associated with fewer adverse events than chemotherapy, and therefore a better quality of life. As researchers discover molecular pathways that drive specific cancers, drugs can be designed to block those pathways. Targeted treatments have not been discovered or developed yet for all types of cancer, but the insights from CGP helped Jennifer’s physician find the individual treatment for her.

Once Dr. Rothenstein put Jennifer on a targeted therapy, she was able to get off chemotherapy and no longer have to endure its side effects. “The treatment worked really well for her,” he said. Unfortunately, Jennifer’s cancer eventually developed resistance to this treatment, so she was subsequently switched to another targeted therapy, also identified through her genomic testing results.

四年后,珍妮弗感觉幸运。“我很幸运能够在这个年龄段,在那里有很多重视研发,”詹妮弗说。bob下载地址“除了我收到的精彩医疗保健外,我的家人都有精彩的支持。”

The next evolution in cancer testing: liquid biopsies

一种s scientists’ understanding of the underlying causes of cancer has evolved, so have the options for CGP. CGP of biopsies can be done with a tissue sample of the tumour, or by drawing blood, since most cancer cells release DNA into the blood. Although tissue-based CGP remains the standard of care, these two types of biopsies are complementary, giving physicians options depending on the patient’s condition and personal circumstances.

例如,在做组织活检时,液体活组织检查可能是困难的,例如当肿瘤处于难以达到的位置时,或者在没有足够的组织时。例如,大约20%的非小细胞肺癌(NSCLC)患者在被诊断bob投注平台为标准组织类基因组测试时可用足够的组织。

对于患者bob投注平台来说,液体活组织检查更简单,更微弱的侵入性,因为它们仅需要单次血液绘制,这可以在门外设定中进行。由于测试简单,它允许更快的测试和治疗,减少应力患者可能会等待安排活组织检查,并减少与某些组织活检相关的疼痛或不适,具体取决于他们的位置。bob投注平台测试的简单性也意味着医生可以更快地获得结果,这对于晚期癌症的患者尤为重要。bob投注平台由于医生可以使用血液样本监测癌症的进展,因此它们可能能够跳过组织活检程序。液体活组织检查可以在门外甚至移动设置中施用,因此它们也可以减少医疗组织的工作量。

For patients like Jennifer, genomic testing was a game-changer in the course of her advanced disease. As it gets easier, with liquid biopsies, physicians and patients will have high-quality options to use genomic testing to get the optimal therapy, for the best outcome.

“I think we are evolving to a place where genomic profiling will be part of a routine when a patient gets diagnosed with cancer,” says Dr. Rothenstein.

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